解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:Development of an easy to administer, low-cost test of vestibular function. METHODS:Members of the NIH Toolbox Sensory Domain Vestibular, Vision, and Motor subdomain teams collaborated to identify 2 tests: 1) Dynamic Visual Acuity (DVA), and 2) the Balance Accelerometry Measure (BAM). Extensive work was comp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182872c6a
更新日期:2013-03-12 00:00:00
abstract:OBJECTIVE:To track cognitive and language changes over time in patients with logopenic (lv-PPA) and semantic (sv-PPA) variants of primary progressive aphasia (PPA). METHODS:Thirteen consecutive patients with lv-PPA and 11 patients with sv-PPA underwent yearly evaluation for a mean of 3 years. Nineteen patients (11 lv-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318285c15b
更新日期:2013-03-05 00:00:00
abstract:OBJECTIVE:To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging. METHODS:Participants, aged 70-92 years, were enrolled in either the Mayo Clinic Study of Aging (n = 246) or the Mayo Alzheimer's Disease Research Center (n = 14). All underwent 2 or more serial amyloid PET examinatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182840bbe
更新日期:2013-03-05 00:00:00
abstract:OBJECTIVE:The objective of the present work is to examine images of the brain dissection by Flemish-born anatomist Andreas Vesalius (1514-1564) as originally represented in the Fabrica (1543), and later copied without Vesalius' permission by Spanish anatomist Juan Valverde de Hamusco (c1525-c1587) in Historia de la com...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e31828407dc
更新日期:2013-02-26 00:00:00
abstract:OBJECTIVE:We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubule-associated protein tau and progranulin mutations. METHODS:In this case-control study, 75 healthy individuals (aged 20-70 year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828407bc
更新日期:2013-02-26 00:00:00
abstract:OBJECTIVE:To evaluate the incidence, baseline characteristics, and clinical prognosis of blood-brain barrier (BBB) disruption after endovascular therapy in acute ischemic stroke patients. METHODS:A total of 220 patients treated with endovascular therapy between April 2007 and October 2011 were identified from a prospe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828406de
更新日期:2013-02-26 00:00:00
abstract:OBJECTIVES:Despite many neuropsychological studies to differentiate subcortical vascular dementia (SVaD) from Alzheimer disease (AD), previous studies did not eliminate confounding effects of mixed Alzheimer and vascular pathology. We aimed to investigate neuropsychological differences between patients with Pittsburgh ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182815485
更新日期:2013-02-05 00:00:00
abstract::A 50-year-old woman with a history of metastatic malignant thymoma presented with diffuse neuropathic pain involving the extremities and torso prior to chemotherapy and radiation. She also developed episodic diarrhea, diaphoresis, fevers, insomnia, and encephalopathy. Examination revealed rippling muscles (video on th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0fa1
更新日期:2013-01-29 00:00:00
abstract:OBJECTIVE:To report the development of CNS vasculitis in a patient with multiple sclerosis (MS) treated with daclizumab. METHODS:This report includes clinical, MRI, immunologic, and pathology data and CSF analysis. RESULTS:After completing a phase II daclizumab monotherapy study with an optimal response as evidenced ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0f42
更新日期:2013-01-29 00:00:00
abstract:OBJECTIVES:Determine the frequency of and the predictive factors for abnormal ocular fundus findings among emergency department (ED) headache patients. METHODS:Cross-sectional study of prospectively enrolled adult patients presenting to our ED with a chief complaint of headache. Ocular fundus photographs were obtained...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0f20
更新日期:2013-01-29 00:00:00
abstract:OBJECTIVE:Recent publications show that using imagery instructions, brain activation patterns indicating consciousness can be found in approximately 10% of patients with unresponsive wakefulness syndrome (UWS; previously called vegetative state). It is possible, however, that patients who cannot follow instructions (be...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0846
更新日期:2013-01-22 00:00:00
abstract:OBJECTIVE:To assess the frequency of mutations in C19orf12 in the greater neurodegeneration with brain iron accumulation (NBIA) population and further characterize the associated phenotype. METHODS:Samples from 161 individuals with idiopathic NBIA were screened, and C19orf12 mutations were identified in 23 subjects. D...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827e07be
更新日期:2013-01-15 00:00:00
abstract::A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827deb63
更新日期:2013-01-15 00:00:00
abstract::Functional brain imaging has been a standard tool in the basic and clinical neurosciences for at least 2 decades, and structural brain imaging can claim an even longer track record of successful use for diagnosis of neurodegenerative disease. It is instructive to recall the ways in which brain imaging has been used to...
journal_title:Neurology
pub_type: 评论,社论
doi:10.1212/WNL.0b013e31827b9305
更新日期:2013-01-08 00:00:00
abstract:OBJECTIVE:This study analyzed the relationship between performance on the American Academy of Neurology Residency In-Service Training Examination (RITE) and subsequent performance on the American Board of Psychiatry and Neurology (ABPN) Certification Examination. METHODS:Pearson correlation coefficients were used to e...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827b92a3
更新日期:2013-01-08 00:00:00
abstract:OBJECTIVE:To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT). METHODS:One hundred sixty-four patients with MS an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827b1a1c
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Spinal cord (SC) lesions are frequently found in multiple sclerosis (MS), but are rare in healthy aging and cerebrovascular patients. Our aim was to analyze the contribution of SC involvement in clinically isolated syndrome (CIS) in diagnosing MS according the McDonald 2010 criteria and in predicting conversi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827b1a67
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Brain changes occurring early in HIV infection are not well characterized. The Chicago Early HIV Infection Study aimed to evaluate the presence and extent of structural brain alterations using quantitative MRI. METHODS:Forty-three HIV and 21 control subjects were enrolled. Mean length of infection was estima...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318278b5b4
更新日期:2012-12-11 00:00:00
abstract::Since the first development of diagnostic criteria for multiple sclerosis (MS), there have been regular revisions of disease definitions and diagnostic thresholds aimed at improving specificity while maintaining sensitivity. The central requirements for diagnosis of MS are dissemination in space (DIS) and disseminatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318277d144
更新日期:2012-12-04 00:00:00
abstract:OBJECTIVE:We sought to identify intracranial EEG patterns characteristic of epileptogenic tubers and to understand the contribution of perituberal cortex. METHODS:Twenty-three intracranial EEG monitoring studies were reviewed from 17 children aged 1.3-7.7 years with tuberous sclerosis complex and intractable multifoca...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182768923
更新日期:2012-12-04 00:00:00
abstract:OBJECTIVE:To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS:Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS:Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%),...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182752d0e
更新日期:2012-11-20 00:00:00
abstract:OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182749f02
更新日期:2012-11-13 00:00:00
abstract:OBJECTIVE:Brain atrophy is common in subcortical ischemic vascular disease, but the underlying mechanisms are poorly understood. We set out to examine the effects of incident subcortical infarcts on cortical morphology. METHODS:A total of 276 subjects with cerebral autosomal dominant arteriopathy with subcortical infa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182749f39
更新日期:2012-11-13 00:00:00
abstract:OBJECTIVE:This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS). METHODS:A total of 68 consecutive cases with symptomatic IAS, diagnosed by imaging, were en...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e318271f76a
更新日期:2012-10-30 00:00:00
abstract:OBJECTIVE:Parkinson disease (PD), a devastating neurodegenerative disorder, affects motor abilities and cognition as well. It is not clear whether the proapoptotic protein, Bid, is involved in tumor necrosis factor death receptor I (TNFRI)-mediated destructive signal transduction pathways such as cell dysfunction or ne...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182703f76
更新日期:2012-10-23 00:00:00
abstract:OBJECTIVE:To assess the available evidence for the diagnostic accuracy of CSF testing for protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD). METHODS:The authors performed a systematic review of the available literature from 1995 to January 1, 2011, to identify articles involving patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826d5fc3
更新日期:2012-10-02 00:00:00
abstract:OBJECTIVE:We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza. METHODS:Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, f...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31826d5ea7
更新日期:2012-10-02 00:00:00
abstract::Revascularization time windows for patients with acute ischemic stroke are generally restricted to 8 hours. Later treatment attempts require more accurate prediction of risk and benefit, as safety and efficacy at these time strata are less well demonstrated. Advanced imaging techniques identify irreversible infarction...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182695826
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVE:Cell-based therapies are being investigated as an adjunct to IV thrombolysis or mechanical thrombectomy in ischemic stroke. This review summarizes the potential applications as well as challenges of intravascular cell delivery in ischemic stroke. METHOD:We conducted a search of Medline as well as the clinica...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e31826959d2
更新日期:2012-09-25 00:00:00
abstract::Endovascular therapy for acute ischemic stroke continues to evolve to improve both efficacy and safety. In the late 1990 s, intra-arterial chemical thrombolysis with prourokinase was shown to be effective in achieving partial recanalization and improving clinical outcome, in comparison with intra-arterial heparin admi...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182697e9e
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVE:To examine the association between cognitive function and dementia with vitamin D concentration in adults. METHODS:Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of glo...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0b013e31826c197f
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVE:The assessment of behavioral disturbances in amyotrophic lateral sclerosis (ALS) is important because of the overlap with the behavioral variant of frontotemporal dementia (ALS-bvFTD). Motor symptoms and dysarthria are not taken into account in currently used behavioral questionnaires. We examined the clinime...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826c1aa1
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVES:Patients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a risk factor for these outcomes. METHODS:Between 2005 and 2007, survivors o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826aacd4
更新日期:2012-09-18 00:00:00
abstract:OBJECTIVE:Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT). With a focus on Singapore, this analysis identifies circumstances in which ge...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826aac73
更新日期:2012-09-18 00:00:00
abstract:OBJECTIVE:Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, affecting 1 in 2,500 individuals. Mitochondrial DNA (mtDNA) mutations are not generally considered within the differential diagnosis of patients with uncomplicated inherited neuropathy, despite the essential requirement of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182698d8d
更新日期:2012-09-11 00:00:00
abstract:OBJECTIVE:To study the accuracy of the ABCD2 score in predicting early stroke risk following TIA and to model post-test probability of stroke for varying cutoff scores and baseline stroke risk. METHODS:Medline, PubMed, Embase, conference proceedings, and manuscript references up to October 2010 were searched for studi...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0b013e31825f9d02
更新日期:2012-09-04 00:00:00
abstract:OBJECTIVE:The purpose of this cross-sectional study was to determine the prevalence and potential significance of stroke symptoms among end-stage renal disease (ESRD) patients without a prior diagnosis of stroke or TIA. METHODS:We enrolled 148 participants with ESRD from 5 clinics. Stroke symptoms and functional statu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826845e9
更新日期:2012-09-04 00:00:00
abstract:OBJECTIVES:While plasma biomarkers have been proposed to aid in the clinical diagnosis of Alzheimer disease (AD), few biomarkers have been validated in independent patient cohorts. Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheim...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e318266fa70
更新日期:2012-08-28 00:00:00
abstract:OBJECTIVE:We developed the Recurrence and Recovery Questionnaire (RRQ) by converting the Pediatric Stroke Outcome Measure (PSOM) to a questionnaire for telephone interview and sought to validate the RRQ in a large cohort. METHOD:We analyzed parents' RRQ responses and same-day PSOM assessments for 232 children who had ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318266fc9a
更新日期:2012-08-28 00:00:00
abstract:OBJECTIVE:Since Alzheimer disease (AD) is a slowly progressive disorder and its pathologic features are likely to be present for many years before symptoms become manifest, we investigated whether microstructural white matter changes similar to those identified in patients with AD can be detected in cognitively normal ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182661f4d
更新日期:2012-08-21 00:00:00